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Schedule of Events Monday, September 6 Venue: Forum Hotel Cracow, Conference Centre, Krakow, ul. Konopnickiej 28 08:30 - Bus to the Forum Hotel 09:15-09:40 Opening Ceremony - Welcoming Remarks - Opening Remarks 09:40-10:40 Plenary Lectures 09:40 Summa Technologiae Toxicologiae Forensis Maciej J. Bogusz Institute of Forensic Medicine, Aachen University of Technology, Germany 10:10 The Power of Drug Testing Edward J.Cone ConeChem Research, Baltimore, MD, USA 10:40 - 11:00 Coffee break Oral Session (11:00 - 12:30): Interpretation of Analytical Results Chairpersons: Marylin A. Huestis, Donald R. A. Uges What is the Definition of Intoxication for Members of TIAFT? Donald R. A. Uges Laboratory for Drug Analysis and Toxicology, Department of Pharmacy University Hospital Groningen and School of Pharmacy University of Groningen, Groningen, The Netherlands An Attempt to Improve the Interpretation of Post-mortem Drug Levels by the Creation of a National Drug-Related Death Database Allan Jamieson Lothian & Borders Police Forensic Science Laboratory Edinburgh, Scotland, UK, (delivered by Anya Hunt) A Two-Fold Variation in the Ratio between the Active and Inactive Enantiomers of the Antidepressant Citalopram in Forensic Autopsy Cases Johan Ahlner*, B. Carlsson, H. Druid, Per Holmgren National Board of Forensic Medicine, Departments of Forensic Chemistry, Forensic Medicine and Clinical Pharmacology, University Hospital, Linköping, Sweden Hemp Tea versus Hemp Milk: Behavioral, Physiological Effects, Blood, Urine, Saliva and Sweat Cannabinoids Levels Following Ingestion by 2 Groups of 6 Healthy Volunteers Christian Giroud*1, Annick Ménétrey1, Marc Augsburger1, Thierry Buclin2 and Patrice Mangin1 1 Laboratoire de toxicologie analytique, Institut universitaire de Médecine Légale, Lausanne, Switzerland 2 Division de Pharmacologie Clinique Lausanne, Switzerland Stability of Drugs in Postmortem Femoral Blood Stored for One Year Per Holmgren*, Johan Ahlner and Henrik Druid National Board of Forensic Medicine, Department of Forensic Chemistry, University Hospital, Linköping, Sweden Statistical Estimation of High Alcohol Concentrations Determined in Breath and in Blood Dariusz Zuba*1, Wojciech Gubala2, Jerzy Labedz2 1 Faculty of Chemistry, Jagiellonian University, Krakow, Poland 2 Institute of Forensic Research, Krakow, Poland The Accuracy of Sequences of Steps in Analytical Procedures in Forensic Toxicology. Its Significance in the Interpretation of the Final Results of Individual Cases of Poisoning Wlodzimierz Gut An independent expert in toxicology. Krakow, Poland (private address) 12:10 Discussion 12:30-14:00 Lunch Oral Session (14:00-16:30): Drugs of Abuse and Doping Chairpersons: Vina Spiehler, Albert D. Fraser The Canadian Centre for Ethics in Sport and Doping Control in Canada Albert D. Fraser Toxicology Laboratory, Queen Elizabeth II Health Sciences Centre and Dalhousie University, Halifax, Nova Scotia, Canada Heroin-related Fatalities in Victoria-Australia 1997-1998: A Study of 434 Cases Jim Gerostamoulos*, Voula Staikos, and Olaf H. Drummer Victorian Institute of Forensic Medicine & Department of Forensic Medicine Monash University, Melbourne, Australia Hair Analysis of beta-Adrenergic Compounds in Doping Control Veronique Dumestre-Toulet*1, Vincent Cirimele2, J. P. Goulle3, Pascal Kintz2 1 Laboratoire Ruffié & Associés, Bordeaux, France 2 Institut de Médecine Légale, Strasbourg, France 3 Laboratoire de biochimie et pharmacocinétique - CHU, Le Havre, France Tragic Flying Attempt under the Influence of "Magic Mushrooms" G. Asselborn, Robert Wennig* and M. Yegles Laboratoire National de Santé, Division Toxicologie, CRP-Santé, Centre Universitaire, Luxembourg Arrestee Drug Abuse Monitoring (ADAM) Program: Distinguishing Crack from Powder Cocaine Use with Urine and Hair Samples Natalie T. Lu*, K. Jack Riley, James E. Meeker National Institute of Justice, Department of Justice Washington, USA Detection of Cocaine and its Major Metabolites in Plasma and Urine Samples in an Emergency Medicine Setting Using Solid-Phase Extraction and GC-MS R. H. Williams1, J. A. Maggiore1, S. M. Shah1, T. E. Erickson2 and Adam Negrusz*3 1 Department of Pathology, 2 Department of Emergency Medicine, 3 Department of Pharmaceutics and Pharmacodynamics, University of Illinois at Chicago Medical Center, Chicago, USA Simultaneous Extraction, Derivatisation and Analysis of Acidic, Neutral and Basic Drugs from Urine by Solid Phase Extraction and Gas Chromatography/Mass Spectrometry Sue Paterson*, Rosa Cordero, Philip Houldsworth Toxicology Unit, Imperial College School of Medicine, London, UK Monitoring of Olanzapine in Serum by Liquid Chromatography-Atmospheric Pressure Chemical Ionization Mass Spectrometry Maciej J. Bogusz*1, Klaus D. Krüger1, Rolf D. Maier1, Rolf Erkwoh2 and F. Tuchtenhagen2 1 Institute of Forensic Medicine, Aachen University of Technology, Germany 2 Clinic of Psychiatry, Aachen University of Technology, Germany 15:20 Coffee break "General Unknown" Screening of Xenobiotics in Plasma by LC-ES-MS P. Marquet*1, N. Vénisse1, J. M. Gaulier1, E. Lacassie1, E. Duchoslav2, B. Shushan2, J. Anacleto2, J. L. Dupuy1, G. Lachatre12 1 Department of Pharmacology and Toxicology, University Hospital, Limoges, France 2 PE-Sciex, Concord, ON, Canada 3 Laboratory of Toxicology, Faculty of Pharmacy, Limoges, France Determination of GHB in Serum or Plasma with GC/MS Alain G. Verstraete*1, Eric Van de Velde1, Peter De Paepe2 1 Laboratory of Clinical Biology-Toxicology, 2 Heymans Institute of Pharmacology, Gent, Belgium The Sensitive and Selective Determination of Clenbuterol, Anabolic Steroids and Metabolites Bernard Rotweiler Helwett Packard, European Support and Marketing Centre, Waldbronn, Germany 16:30 Discussion Poster Session (17:00-18:00) Discussion Chairpersons: Edward J. Cone, Robert Anderson 1. Surface Ionization Mass Spectrometry. Selective Determination of Trace Amounts of Opioids in Urine U. Kh. Rasulev1, Usman Khasanov1, Turgun Kh. Islamov2, Makhamudjan M. Shakhitov3, B. Eshmuratov3 1 Arifov Institute of Electronics, Tashkent, Uzbekistan 2 Republican Criminal Research Center, Tashkent, Uzbekistan 3 Republican Bureau of Forensic Medicine Expertise, Tashkent, Uzbekistan 2. Diagnosis of Illicit Drug Overdoses: Difficulties Found Estela G. P. Marques, Alice M. Castanheira, Paula Proença, Paula V. Monsanto, Sofia A. Oliveira, Sofia Avila, Duarte N. Vieira Instituto de Medicina Legal de Coimbra, Coimbra. Portugal 3. Heroin Cases in Routine Forensic Toxicological Examination of Biological Fluids Aniko Kovacs, Zsuzsanna Miko Hideg and Andras Benko* National Institute of Forensic Toxicology, Budapest, Hungary 4. The Role of Ethanol in Cocaine Concentration in Human Postmortem Whole Blood Alice A. da Matta Chasin*1, and A. F. Mídio2 1 Medical Legal Institute of Sao Paulo, Brazil 2 Department of Toxicology, University of Sao Paulo, Sao Paulo, Brazil 5. Benzodiazepine Findings in Blood and Urine by Gas Chromatography and Immunoassay Ilpo Rasanen*, Ilkka Ojanpera and Erkki Vuori Department of Forensic Medicine, University of Helsinki, Finland 6. Parathion and Acute Intoxication. The Importance of Toxicological Analytic Tests Estela G. P. Marques*, M. M. Oliveira, Paula V. Monsanto, Paula Proença, Fernando Castanheira, Duarte N. Vieira Instituto de Medicina Legal de Coimbra, Coimbra, Portugal 7. Distribution of Hydrogen Sulphide in Rats' Organs and Associated Histological Changes in Experimental Intoxication Roman Wachowiak1, J. Miskowiak2, Jaroslaw Tobolski1 1 Dept. of Forensic Medicine, University of Medical Science, Poznan, Poland 2 Dept. of Histology and Embryology University of Medical Science, Poznan, Poland 8. Pyrolysis of Cocaine to Methyl Ecgonidine and Subsequent Metabolic and Hydrolytic Transformation to Ecgonidine Buddha D. Paul Division of Forensic Toxicology, Office of the Armed Forces Medical Examiner, Armed Forces, Institute of Pathology, Rockville, USA 9. Comparison of GC-MS and LC-MS Methods for Quantification of Morphine and its 3- and 6- Glucuronides, Codeine, Codeine-glucuronide and 6-Monoacetylmorphine in Human Serum for Routine Analysis in Forensic Toxicology Laurent Rivier*, Agnes Dienes and Patrice Mangin Institut Universitaire de Médecine Légale, Lausanne, Switzerland 10. Detection Times for Opiates in Urine after Various Doses of Heroin Using Different Screening Methods Michael L. Smith*1, Buddha D. Paul1, Jacqueline Summers1, Karla A. Moore1, Amanda Jenkins2, William D. Darwin2, Edward J. Cone2, Dan Nichols3, and Edwin K. Armitage3 1 Division of Forensic Toxicology, Armed Forces Institute of Pathology, Washington, DC, USA 2 Addiction Research Center, IRP, NIDA, NIH, Baltimore, MD, USA 3 US Army Forensic Toxicology Drug Testing Laboratory, Fort Meade, MD, USA 11. Determination of Various Opiates Including Hydrocodone and Hydromorphone in Biosamples by GC-MS after Silylation Marie Baliikova*, Vera Maresova Institute for Toxicology and Forensic Chemistry, Charles University, 1st Medical Faculty and Hospital, Prague, Czech Republic 12. Analysis of Underivatized Amphetamines and Related Phenethylamines with High Performance Liquid Chromatography-Atmospheric Pressure Chemical Ionization Mass Spectrometry Maciej J. Bogusz*, Klaus D. Krüger and Rolf-D. Maier Institute of Forensic Medicine, Aachen University of Technology, Germany 13. Clean-up Process for Mass Spectral Study of Amphetamines in Putrefied Body Materials Kenji Hara*, Seiichi Kashimura, Masayuki Kashiwagi, Tomoko Hamanaka and Mitsuyoshi Kageura Department of Forensic Medicine, Fukuoka University School of Medicine, Fukuoka, Japan 14. Capillary Electrophoretic Enanthiomer Separation of Amphetamines after the Administration of l-Deprenyl to Man Eunmi Kim1, Sunchun Kim1, Heesun Chung*1, Youngchan Yoo1, Kongju Lee2 and Hwajung Kim2 1 National Institute of Scientific Investigation, Seoul, Korea 2 College of Pharmacy, Ewha Women's University, Seoul, Korea 15. Evaluation of Sample Preparation Techniques Adequate for Multivariate Algorithms Applied for the Identification and Classification of Amphetamine Analogues with GC-FTIR Mirela Praisler2, Inge Dirinck*2, Willy Lambert, Andreas De Leenheer, and D. Luc Massart3 1 Laboratory of Toxicology, Universiteit Gent, Gent, Belgium 2 Department of Physics, University of Galati, Galati, Romania 3 Laboratory of Pharmaceutical and Biomedical Analysis, Vrije Universiteit Brussel, Brussel, Belgium 16. Comparison between Automated Knowledge-Based Systems Identifying and Classifying Amphetamine Analogues using Vapour-phase FTIR Spectra and Mass Spectra Inge Dirinck*1, Mirela Praisler2, Jan Van Bocxlaer, Andreas De Leenheer and D. Luc Massart3 1 Laboratory of Toxicology, Universiteit Gent, Gent, Belgium 2 Department of Physics, University of Galati, Galati, Romania 3 Laboratory of Pharmaceutical and Biomedical Analysis, Vrije Universiteit Brussel, Brussel, Belgium 18:00 Bus to hotels 18:45 Bus to concert 19:30 Organ Concert at Mariacki (St. Mary's) Church Rynek Glowny (Mariacki Square 5) 20:45 Bus to hotels Tuesday - September 7 08:00 Bus to the Forum Hotel Day-long recreational raft trip down the Dunajec river Wednesday - September 8 08:15 Bus to the Forum Hotel Oral Session (9:00-10:40): Validation of Analytical Procedures Chairpersons: Anya Pierce, Maciej J. Bogusz Evaluation of Abselut? SPE Columns for Broad Spectrum Drug Screening in Plasma and Urine using GC-FID and HPLC-DAD Jan Bosman, Jaap Wijsbeek, Jan Piet Franke and Rokus A. de Zeeuw* Department of Analytical Chemistry and Toxicology, University Centre for Pharmacy, Groningen, The Netherlands Selectivity of Photodiode Array UV-Spectra for Substance Identification in Systematic Toxicological Analysis Matthias Herzler*, Fritz Pragst, Sieglinde Herre and Michael Rothe Institute of Legal Medicine, Humboldt-University, Berlin, Germany Screening for Drugs in Serum by ESI/CID and Library Searching Wolfgang Weinmann*1, Michaela Renz1, Michal Svoboda2 1 Institute of Legal Medicine, University of Freiburg, Freiburg, FRG 2 Perkin-Elmer Biosystems, Langen, FRG The Combination of Two-Dimensional Thin Layer Chromatography and Remission Spectrometry - a Chromatographic Technique with High Identification Power for Systematic Toxicological Analysis Ulrich Demme*, Björn Ahrens, Annelies Klein and Rolf Werner Institute of Forensic Medicine, University of Jena, Germany Simultaneous Analysis of Sildenafil and Metabolites in Serum and Urine by High-Performance Liquid Chromatography with Diode-Array Detection Marc Deveaux*1, Bertille Willaume1, Francis Collier2, Valery Hedouin1, Gilles Tournel1, Didier Gosset1 1 Institut de Médecine Légale, Lille, France 2 Hopital Jeanne de Flandre, Lille cedex, France Extraction and Analysis of Flunitrazepam and Metabolites in Urine using SPE-HPLC-DAD Anya L. Hunt* and D. Zeitlin Forensic Science Unit, University of Strathclyde, Glasgow, UK Sensitive Determination of Mianserin and Setiptiline in Body Fluids by Gas Chromatography with Surface Ionization Detector (GC-SID) Akira Ishii*1, Hiroshi Seno2, Kanako Watanabe-Suzuki2, Takeshi Kumazawa3, Osamu Suzuki2 and Yoshinao Katsumata 1 Department of Legal Medicine and Bioethics, Nagoya University School of Medicine, Nagoya, Japan 2 Department of Legal Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan 3 Department of Legal Medicine, Showa University School of Medicine, Tokyo, Japan 10:10 Discussion 10:40 Coffee break Oral Session (11:00-11:50) Analysis of Alternative Materials Chairpersons: Robert Wennig, Manfred Moeller Elimination of Cocaine and Metabolites in Saliva following Repeated Oral Cocaine Administration Rebecca A. Jufer*1, Sharon L. Walsh2, and Edward J. Cone1 1 Addiction Research Centre, IRP, NIDA, Baltimore, USA 2 Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, USA The Application of Opiate Determination in Saliva for Diagnostic and Prognostic Purposes during Detoxification of Addicted Persons Ewa Janowska1, Wojciech Piekoszewski*1, Janusz Pach2, Lidia Winnik2 1 Institute of Forensic Research, Krakow, Poland 2 Department of Clinical Toxicology, Collegium Medicum, Krakow, Poland Testing for the Anabolic Steroid DHEA in Human Hair Pascal Kintz*1, Vincent Cirimele1, Marc Deveaux2 and Bertrand Ludes1 1 Institut de Médecine Légale, Strasbourg, France 2 Institut de Médecine Légale, Lille, France Comparative Efficiency of Hair and Urine Analysis when Assessing Drug Consumption Carmen Jurado*, Teresa Soriano, Manuel Menéndez and Manuel Repetto Instituto Nacional de Toxicología, Sevilla. Spain The Development of a Liquid Chromatography - Mass Spectrometry Method for the Detection of Allopurinol and its Metabolites in Human Hair Tamsin Kelly*1, Costa Conn1, Ken Williams2, Harry Rose1, Jim Keegan1 1 Department of Chemistry, Materials and Forensic Sciences, University of Technology, Sydney, Australia 2 Clinical Pharmacology, St Vincent's Hospital, Darlinghurst, Australia Oral session (11:50-12:40) Driving under the Influence The German Approach to Solving the Problem of Driving under the Influence of Drugs Manfred R. Moeller*, Stefan Steinmeyer, and Stefan Bregel Institute of Legal Medicine, Saarland University, Homburg/Saar, Germany The Elaboration of the New 'Per se' Legislation on Drugs and Driving in Belgium: an Insider's View Alain G. Verstraete*1, Viviane A. Maes2 1 Laboratory of Clinical Biology-Toxicology, University Hospital, Gent, Belgium 2 Department of Clinical Chemistry-Toxicology, Academic Hospital, Free University of Brussels, Belgium Cutoff Concentrations for Drugs of Abuse in Saliva for DUI, DWI or other Driving-Related Crimes Vina Spiehler*1, Dene Baldwin2, Christopher Hand2 1 Newport Beach, USA 2 Cozart Bioscience Ltd, Abingdon, Oxfords, UK Capillary Electrophoresis Instruments and Techniques for Forensic Toxicology Problem Solving Jerzy Superata MEDIM (Beckman Coulter), Warszawa, Poland 12:20 Discussion 12:40-14:00 Lunch Poster Session (14:30-16:00) Discussion Chairpersons: Pascal Kintz, Wojciech Piekoszewski 17. Multicenter Study on Reproducibility of Mass Spectra of Toxicologically Relevant Drugs Generated by Atmospheric Pressure Ionization Mass Spectrometer Maciej J. Bogusz*1, Rolf-Dieter Maier1, Klaus D. Krüger1, Kenneth S. Webb2, Julie Romeril2, Mark L. Miller3 1 Institute of Forensic Medicine, Aachen University of Technology, Germany 2 Laboratory of the Government Chemist, Teddington, UK 3 Forensic Science Research and Teaching Center, FBI Academy, Quantico, USA 18. Microextraction in Bioanalysis of Drugs Mette Krogh National Institute of Forensic Toxicology, Sentrum, Oslo, Norway 19. Determination of GHB by Head-Space GC/MS in Forensic Samples Sys Stybe Johansen* and Soren Felby Institute of Forensic Medicine, Frederik V´s vej 11, University of Copenhagen, Copenhagen, Denmark 20. The Determination of GHB in Biological and Adulterated Samples without Forming Gamma-Butyrolactone Thomas F. August*, Chester J. Kitchen and Michael Telepchak United Chemical Technologies Inc., Bristol, USA 21. Pharmacokinetic Study of Dextromethorphan with Urinary Excretion Heesun Chung*, Wonkyung Yang, Hwakyung Choi, Wontack Jin, Sihnyoung Sihn and Youngchan Yoo National Institute of Scientific Investigation, Seoul, Korea 22. Surface Ionization Mass Spectrometry. Analysis of Post-Mortems for Fatal Poisoning by Chlorpromazine U. Kh. Rasulev1, Usman Khasanov1, Turgun Kh. Islamov2, Makhamudjan M. Shakhitov3, B. Eshmuratov3 1 Arifov Institute of Electronics, Tashkent, Uzbekistan 2 Republican Criminal Research Center, Tashkent, Uzbekistan 3 Republican Bureau of Forensic Medicine Expertise, Tashkent, Uzbekistan 23. Urinary Excretion of Diazepam Metabolites in Healthy Volunteers Taking a Single Dose of Diazepam, and in Drug Users Anne Smith-Kielland*, Bjorn Skuterud, Kirsten M. Olsen, Anne C. P. Jorgensen, Jorg Morland National Institute of Forensic Toxicology, Oslo, Norway 24. Screening for the Presence of para-Methylthioamphetamine in Urine by some Commercial Immunoassays and Confirmation by GC/MS Ingrid J. Bosman*1, Douwe de Boer2 and Robert A. A. Maes1 1 Department of Human Toxicology, Utrecht Institute of Pharmaceutical Sciences, Utrecht, The Netherlands 2 Laboratorio de Analises de Dopagem e Bioquimica, Lisboa, Portugal 25. Mutagenic Effects of the Food Colour Erythrosine in Rats Hamdy A. Mekkawy*1, A. A. Massoud2, A. M. El-Zawahry3 1 The National Center for Social and Criminological Research, P.O. Zamalek, P.C.11561, Cairo, Egypt 2 Faculty of Sciences, Tanta University, Tanta, Egypt 3 NODCAR, Cairo, Egypt 26. Coma after Intake of Gamma-Hydroxybutyric acid (GBH): Two Case Report Peter X. Iten*1, Andrea Oestreich1, Regina Lips2, and Michael Brabetz2 1 Institute of Legal Medicine, University of Zurich, Zurich, Switzerland 2 Waid Hospital, Zurich, Switzerland 27. Direct Extraction of Benzodiazepine Metabolites with Supercritical Fluid from Whole Blood Kenichi Takaichi, Shuji Saitoh, Yoshio Kumooka, and Noriko Tsunoda National Research Institute of Police Science, Chiba, Japan 28. Application of Gas Chromatography to the Identification of Petroleum Products in Environmental Contamination Cases Zofia Chlobowska, Ewa Chudzikiewicz, CzesLawa Swiegoda, Wojciech Piekoszewski Institute of Forensic Research, Krakow, Poland 29. Comparison of an Enzymatic Alcohol Dehydrogenase Assay and Alcohol Headspace GC-FID Method Using Statistical Analysis on Real Forensic Blood and Urine Samples Katrien Arys*, J. Van Bocxlaer, Willy Lambert, C. Van Peteghem and Andreas De Leenheer Laboratorium voor Toxicologie, Universiteit Gent, Faculteit Farmaceutische Wetenschappen, Gent, Belgium 30. Simultaneous Determination of Triazolam and its Metabolites in Human Blood and Urine by GC-MS Keiko Kudo*, Noriaki Ikeda and Yukiko Hino Department of Forensic Medicine Faculty of Medicine, Kyushu University, Fukuoka, Japan 31. Analysis of Meconium for Amphetamines and Opiates. Our First Experience Eva Novakova Institute for Toxicology and Forensic Chemistry, Charles University and University General Hospital, Prague, Czech Republic 32. Involvement of Drugs in Accident Causation Jim Gerostamoulos*, Helen Batziris (Hons) and Olaf H. Drummer Victorian Institute of Forensic Medicine & Department of Forensic Medicine - Monash University, Melbourne, Australia 33. Risks for Driving under the Influence of Clomethiazole Enno Logemann Institute of Forensic Medicine, University of Freiburg/Brsg., Germany 34. Fatal Traffic Accidents Influenced by Drugs in South Moravia in 1998 Helena Samkova*, Andrea Brzobohata, Miroslav Hirt Institute of Forensic Medicine, Brno, Czech Republic 35. Drugs of Abuse: On-Site Saliva Sampling and Analysis Jörg Zimmermann*1,2, Hans-Jürgen Duchstein1, Kai Bierans2, Thomas Wuske3, Rainer Polzius3, Andreas Manns2 1 University of Hamburg, Institute of Pharmacy, Hamburg, Germany 2 Drager Sicherheitstechnik GmbH, Lubeck, Germany 3 Dragerwerk AG, Lubeck, Germany 36. Identification of Basic Drugs in Forensic Samples by Capillary Gas Chromatography Irene Breum Müller Institute of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark 37. The Decision to Use Modern Gas Chromatography/Mass-Spectrometry Methods in Forensic Examination Alexandr Tsymbal Research Institute of Forensic Expertises of the Justice Ministry of Ukraine 38. Investigation of Biological Markers of Chronic Alcoholism Erzsébet Jeszenszky*1, Tibor Varga1, Peter Freudenstein2, Wolfgang Bonte2 1 Albert Szent-Gyorgyi Medical University, Department of Forensic Medecine, Szeged, Hungary 2 Heinrich Heine University, Department of Forensic Medicine, Dusseldorf, Germany 39. Methadone Substitution Therapy Program and Toxicological Studies Halina Matsumoto*, Elzbieta Wozny, Anna Dziklinska, Malgorzata Abramowska The University Medical School of Warsaw, I Department of Psychiatry, Laboratory of Psychopharmacology, Warsaw, Poland 40. Salicylamide in Urine after Intake of Acetylsalicylic Acid due to Degradation of Salicylic Acid Conjugates Kurt Besserer1, Detlef Tiess2, Maria Kala*3 1 Formerly Institute of Forensic Medicine, University in Tübingen, Germany 2 Formerly Institute of Forensic Medicine, University in Rostock, Germany 3 Institute of Forensic Research, Cracow, Poland 41. A Simultaneous Determination of Naltrexone and 6-ß-Naltrexol in Serum by HPLC Katja Sarkka, Kari Ariniemi and Pirjo Lillsunde* Laboratory of Substance Abuse, National Public Health Institute, Helsinki, Finland 42. Propofol Metabolism after Excessive Abuse Achim Schmoldt*, S. Iwersen-Bergmann, H. M. Rosner Department of Legal Medicine, University of Hamburg, Hamburg, Germany 43. Fatal Intoxication by Cibenzoline (CIPRALANO) N. Richard, Marie H. Ghysel*,M. Savart Laboratoire de Police Scientifique, Lille, France 16:00-16:30 Coffee break 16:30-18:00 TIAFT Young Scientists Committee Meeting 16:30-18:00 Meeting of European PTP Co-ordinators - room Ewa 16:30 Bus to hotels Thursday - September 9 08:15 Bus to the Forum Hotel Oral Session (9:00-10:30): Free Topics Chairpersons: Yuji Nakahara, Alain Verstrate Buprenorphine and Norbuprenorphine Plasma Concentrations After High Dose IV Drug Administration Marilyn A. Huestis*, Annie Umbricht, Kenzie L. Preston, Edward J. Cone Intramural Research Program, NIDA, NIH, Baltimore, MD, USA Differentiation of Illicit Heroin Abuse from Use of Prescribed Diamorphine using Electron Impact Gas-Chromatography Mass Spectrometry Neil A. McLachlan-Troup, Susan Paterson, Sunella L. Brahma* & Bruce Trathern Toxicology Unit, Imperial College, St. London, United Kingdom Screening for the General Unknown in Tissue Samples by Polystyrene Resins Thomas Stimpfl* and Walter Vycudilik Institute of Forensic Medicine, University of Vienna, Vienna, Austria Optimisation of Solid Phase Microextraction (SPME) Conditions for Headspace Analysis of Organo-Phosphate Pesticides in Whole Blood Kamarruddin Asri*1 and Robert A. Anderson2 1 Department of Chemistry, Selangor, Malaysia 2 Department of Forensic Medicine and Science, University of Glasgow, Glasgow, UK Amantadine Intoxication: Disposition of Amantadine in a Fatal Overdose and Review of the Literature Amanda J. Jenkins and Gary Sebrosky Cuyahoga County Coroner's Office, Cleveland,OH, USA Venlafaxine - Analytical Findings in Clinical and Post-mortem Cases Daniel Martinez*, Manjit Ruprah Medical Toxicology Unit, Guys & St Thomas' Hospital Trust, London, UK 10:00 Discussion 10:30 Coffee break Oral Session (11:00-12:20): Free Topics Chairpersons: Maria Kala, Laurent Rivier Mass Spectral Characterisation of Hepatic Cell Metabolites of D,L-kavain using HPLC and GC/MS Systems Fuad Tarbah*, Hellmut Mahler, Oliver Temme and Thomas Daldrup Institute of Legal Medicine, Heinrich-Heine-University, Duesseldorf, Germany Quantitative Determination of Paraquat by HPLC-DAD following Chemical Reduction with Sodium Borohydride in a Fatal Intoxication Katrien Arys*1, J. Van Bocxlaer1, E. Meyer1, K. Clauwaert1, W. Lambert1, M. Piette2, C. Van Peteghem1 and A. De Leenheer1 1 Laboratorium voor Toxicologie, Universiteit Gent, Faculteit Farmaceutische Wetenschappen, Gent, Belgium 2 Laboratorium voor Gerechtelijke Geneeskunde, Faculteit Geneeskunde, Universiteit Gent, Gent, Belgium Methamphetamine from Thailand with the Logo WY Werner Bernhard*1, Priska Regenscheit1, Beatrice Hayoz1, Alain Broillet1, Beat Aebi1, Michael Frost2, Justus Beike2 1 Institute of Legal Medicine, University of Bern, Bern, Switzerland 2 Institute of Legal Medicine, University of Munster, Münster, Germany 'Phenethylamine' Street Samples Encountered on the Belgian Drug Market Inge Dirinck*, Willy Lambert and Andreas De Leenheer Laboratory of Toxicology, Universiteit Gent, Gent, Belgium Reliability of Clinical Decisions Regarding Alcohol Influence Hasn A. Abder-Rahman, K. A. Hadidi, Abdekkader H. Battah Forensic Medicine and Toxicology Division, Faculty of Medicine, University of Jordan, Amman, Jordan Death Caused by Acute Formaldehyde Poisoning during Haemodialysis Treatment in Hospital Vincent K.K. Mok*, David T.W. Chan Government Laboratory, Homantin Government Offices, Kowloon, Hong Kong 12:00 Discussion 12:20-14:00 Lunch - Sponsored by Dade Behring Poster Session (14:00-15:00) Discussion Chairpersons: Werner Bernhard, Mark B. Lewis 44. Analysis of Estazolam in Post-mortem Material Ewa Pufal*1, Marzena Sykutera1, Grzegorz Lis1, Gertrud Rohcholz2, Karol Sliwka1 1 Katedra i Zaklad Medycyny Sadowej, Akademia Medyczna w Bydgoszczy, Bydgoszcz, Poland 2 Institut fur Rechtsmedizin, Kiel, Germany 45. Stability of Citalopram, Fluoxetine, Paroxetine and their Metabolites in Plasma and Whole Blood from Spiked and Real Samples Lena Kristoffersen*1, Mette Krogh1, Jorgen G. Bramness1 and Elsa Lundanes2 1 National Institute of Forensic Toxicology, Oslo, Norway 2 Department of Chemistry, University of Oslo, Oslo, Norway 46. Magic Mushrooms: Case Reports, Screening and Detection of Psilocin in Mushrooms and in Urine Werner Bernhard1, Beat Aebi1, Justus Beike2, Michael Frost2 and Herbert Honegger3 1 Institute of Legal Medicine, University of Bern, Bern, Switzerland 2 Institute of Legal Medicine, University of Münster, Münster, Germany 3 Easy - Link AG, Scientific Services, Solothurn, Switzerland 47. Street Drugs in Denmark 1995-1998 Kirsten W. Simonsen*1, E. Kaa1, E. Nielsen2, D. Nielsen3 1 University Institute of Forensic Medicine, Aarhus, Denmark 2 University Institute of Forensic Medicine, Copenhagen, Denmark 3 University Institute of Forensic Medicine, Odense, Denmark 48. The Application of Spectral and X-ray Diffraction Methods in the Analysis of Street Drugs Bretislav Smysl*1, Dagmar Krausova2, Jan Hlavac2 1 Institute of Forensic Medicine and Medical Law of Palacky University, Olomouc, Czech Republic 2 Departments of Analytical and Inorganic Chemistry of Palacky University, Olomouc, Czech Republic 49. Chemical Programmes in Thanatometric Laboratory Volodymyr Bilkun Zaporozhye Medical University, Ukraine 50. Three Cases of Thinner-Intoxication and Estimating the Lethal Concentration of Toluene by Toxicokinetics Tatsuya Hobara, M. Okuda, C. Yamada, H. Kobayashi, M. Gotoh, K. Oki and H. Segawa Department of Public Health Yamaguchi University School of Medicine, Ube, Japan 51. Validation and Quality Assurance of a Broad Scale Gas Chromatographic Screening Method for Drugs Merja Gergov*, Jari Nokua, Ilpo Rasanen and Ilkka Ojanpera Department of Forensic Medicine, University of Helsinki, Helsinki, Finland 52. Human Liver Carboxylesterases: Purification of these Two Enzymes, Properties in Relation to Cocaine and Alcohol Metabolism, and Specificities Karine Berthoin*1,2, Francois Widmer3, Christian Giroud2, Patrice Mangin2 and Luc Barret1 1 Laboratoire de Médecine Légale et Toxicologie. UFR de Médecine. Grenoble, France 2 Laboratoire de Toxicologie Analytique. Institut Universitaire de Médecine Légale. Lausanne, Suisse 3 Institut de Biologie et Physiologie Végétales. Lausanne, Suisse Laboratoire de Médecine Légale et Toxicologie. UFR de Médecine. Grenoble, France 53. Paraoxanase and Acetylcholinesterase Activities in Human Exposure to Organophosphorous Compounds Serap A. Akgur*1, P. Ozturk1, E. Y. Sozmen2, Y. Delen2, T. Tanyalcyn2, B. Ege1 1 Ege Unyversity, Department of Forensic Medicine, Turkey 2 Ege Unyversity, Department of Biochemistry, Turkey 54. Distribution of Heavy Metals in Normal Korean Tissues Youngchan Yoo1, Sangki Lee*1, Jayeol Yang1, Sangwhan In1, Kiuk Kim1, Sunchun Kim1, Taejung Kwon1, Youngchang Ko1, Kyuhyuck Chung2 1 National Institute of Scientific Investigation, Seoul, Korea 2 College of Pharmacy, Sungkyunkwan University, Suwon, Korea 55. Aluminum Phosphide Fatalities, New Local Experience Hasn A. Abder-Rahman, Abdelkader H. Battah*, Y. M. Ibraheem, M. S. Shomaf and N. El-Bataineh Faculty of Medicine, University of Jordan, Jordan 56. Hepatotoxicity of Paracetamol and Trichloroethylene Combination in Rats Barbara Zielinska-Psuja*1, Joanna Kowalowka-Zawieja1, Andrzej Plewka2, Jerzy Orlowski1, Marcin Kaminski2 1 Department of Toxicology, Karol Marcinkowski University of Medical Sciences, Poznan, Poland 2 Department of Histology and Embryology, Silesian School of Medicine, Katowice-Ligota, Poland 57. Experimental Data Regarding the Effects of Amiodarone on Pregnant Rats Razvan Gligor*1, Virginia Gligor2 1 UMF Timisoara, Romania 2 University of V. Goldis, Arad, Romania 58. Electrophoretic Analyses of Serum Proteins of Birds and Mammals E. G. E. Helal1, S. A. M Zahkouk2, Hamdy A. Mekkawy3 1 Faculty of Sciences, Al - Azhar University (Girls) 2 Faculty of Sciences, Al - Azhar University (Boys) 3 The National Center for Social and Criminological Research, Zamalek, Cairo, Egypt 59. A Silent Killer of Intelligence: Lead Poisoning in Children in the USA, Thailand, Laos, Mexico, El Salvador, Nigeria and Jamaica Karl Verebey*, Raul Rudelli and Philip Fischer Leadtech Corporation, N. Bergen, NJ, USA Mayo Clinic, Rochester, MN, USA 15:00 Closing Remarks 15:30 TIAFT Business Meeting 18:00 Bus to hotels 19:15 Bus to Niepolomice 20:00 Farewell Banquet at the Royal Castle in Niepolomice 24:00 Bus to hotels