Quest Diagnostics, Inc., 7470 Mission Valley Road, San Diego, CA 92108, USA

Steroid 2, being a precursor of testosterone and other androgens, behaves similarly to 1, causing a brief abnormal increase (100 times) of the major urinary steroids: testosterone, epitestosterone, androsterone, etiocholanolone. Steroid 2, like 1, causes temporary increase of T/E for all but low T/E men. 2 undergoes conversion into numerous specific metabolites as well, especially into 3a- and 3b-ol-4-androsten-17-ones and 1.

Steroid 3, converting into nandrolone, appears in urine mainly as 19-norandrosterone and 19-noretiocholanolone, reaching concentrations in the first voids as high as 100,000 ng/mL. After a single oral dose of 50 mg, these remain detectable for at least 7 days and up to 10 days. 19-Nortestosterone and dehydrometabolites are well detectable during the first day of excretion. "Asian" men with low T/E metabolize 3 into the same main products as others do with one exception: 19-norepitestosterone appears in urine as a main intermediate metabolite, whereas for Caucasians 19-nortestosterone is a major.